Propofol decreases toxic damage to cells from radiograph radiation through inhibition of gap junction activity, according to a study published in the April 2011 issue of Anesthesia & Analgesia.
According to the study, researchers have previously reported that propofol inhibits gap junction function briefly, and a functional GJ enhances the efficacy of radiotherapy in some cancer cells. The study examined the role of propofol in clinically relevant concentrations in the modulation of radiograph-induced cytotoxicity in HeLa cells transfected with connexin 32 plasmid. The role was explored by manipulating connexin expression, GJ presence and function.
The study found that propofol significantly reduced radiograph-induced cytotoxicity in the presence of functional GJ.
Read the study on propofol in Anesthesia & Analgesia.
Read more on anesthesia:
-ASA Updates Guidelines on Chronic Pain Management
-Study: Obese Patients Twice as Likely to Develop Airway Problems During General Anesthesia
According to the study, researchers have previously reported that propofol inhibits gap junction function briefly, and a functional GJ enhances the efficacy of radiotherapy in some cancer cells. The study examined the role of propofol in clinically relevant concentrations in the modulation of radiograph-induced cytotoxicity in HeLa cells transfected with connexin 32 plasmid. The role was explored by manipulating connexin expression, GJ presence and function.
The study found that propofol significantly reduced radiograph-induced cytotoxicity in the presence of functional GJ.
Read the study on propofol in Anesthesia & Analgesia.
Read more on anesthesia:
-ASA Updates Guidelines on Chronic Pain Management
-Study: Obese Patients Twice as Likely to Develop Airway Problems During General Anesthesia